Gene information
Official symbol PDCD1
Official full name programmed cell death 1
Gene type protein-coding gene
Chromosome2q37.3
Alias symbolCD279; PD1; hSLE1; PD-1
Previous symbolSLEB2
Gene familyCD molecules; V-set domain containing
Resources
Entrez Gene 5133
HGNC HGNC:8760
Ensembl ENSG00000188389
Vega OTTHUMG00000151342
UCSC uc002wcq.5
GO terms: 11 records
GO Description Category LogP Number of genes Detail
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0070230 positive regulation of lymphocyte apoptotic process GO Biological Processes -4.38810525 4 More
GO:0070234 positive regulation of T cell apoptotic process GO Biological Processes -3.36388958 3 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
GO:2000108 positive regulation of leukocyte apoptotic process GO Biological Processes -4.82877039 5 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04660 T cell receptor signaling pathway KEGG Pathway -4.46130434 8 More
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer KEGG Pathway -4.03177682 7 More
Drug-Gene interaction
view
Related drugs: 14 records
Drug name Interaction type Source PMID View
amp-224 antibody MyCancerGenomeTTD view
balstilimab TTD view
cemiplimab inhibitorantibody TTD 2986397929089720 view
dostarlimab TTD view
m-7824 TTD view
mga-012 TTD view
nivolumab antibodyinhibitor MyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTTD 23289116 view
pembrolizumab inhibitorantagonistantibody MyCancerGenomeChemblInteractionsTTD 25685857 view
pidilizumab antibody MyCancerGenomeTdgClinicalTrialCancerCommons view
sasanlimab TTD view
sintilimab TTD view
spartalizumab antibody TTD view
sym-021 TTD view
tislelizumab antibody TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NG_012110.1:g.12147G>A genomics myocardial infarction[diagnosis] myocardial infarction Bennet AM et al. Hum Immunol. 2006
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